FIGURE 4 from Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes
Year: 2023
Type: other
Abstract: Subtype methylation and expression of genes previously reported as differentially methylated by HPV status. A, Rain Cloud plot of differential methylation levels in cis-eQTMs across all 70 genes previously found hypermethylated in HPV(+). B–D, Visualization of example genes related to cell adhesion, cell cycle, and differentiation. Figure format is similar to Fig. 3C–F. Gray lines: IMU or KRT versus HPV(−) significant DMRs. Orange lines: significant cis-eQTMs overlapped with gray lines’ DMRs. CCNA1 is an exception where both IMU and KRT HPV+ tumors display hypermethylation compared with HPV(−).
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4386284196