Gut microbiota influence on pulmonary arterial hypertension risk: a Mendelian randomization analysis
Year: 2023
Type: preprint
Study design: Observational Study
Abstract: Background The association between gut microbiota and pulmonary arterial hypertension (PAH) has been found in some observational studies. However, whether this association implies a causal relationship remains unclear. Methods In this study, we employed summary data from genome-wide association studies (GWAS) of the gut microbiota and PAH to investigate the causal relationship between the gut microbiota and PAH using a two-sample Mendelian randomization (MR) design. Comprehensive sensitivity analyses were conducted to ensure the robustness of the results. Results The MR results indicated that genetically predicted abundance of Lachnospiraceae ND3007 group (OR (95% CI):0.251(0.175 ~ 0.360), adjusted P value:<0.001) and Eubacterium fissicatena group (OR (95% CI):0.525(0.411 ~ 0.669), adjusted P value:<0.001) were significantly associated with a reduced risk of PAH. Additionally, we identified 12 gut microbiota, including Eubacterium ventriosum and Ruminococcus torques, that may have potential causal relationships with PAH. Conclusion This study suggests that specific gut microbiota may influence the incidence of PAH. This provides the evidence for a causal relationship between gut microbiota and PAH, thus offering novel insights into the therapeutic and mechanistic research of PAH.
Source: Research Square
Authors: Dongrui Li, Fan Li, Jingyu Jin, Yang Yang, Qian Tong
Institution: First Hospital of Jilin University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4386284274