Relation of forward and backward traveling pressure waves with subclinical carotid artery wall remodeling and central pulse pressure
Year: 2023
Type: article
Study design: Observational Study
Abstract: The present study contributes to the growing body of evidence highlighting the physiological and clinical insight provided by the pulsatile hemodynamic components of central artery pulse pressure. The notable findings of this study are: 1) The reflected (backward) pressure wave is associated with carotid intima-media thickness independent of traditional cardiovascular risk factors, including systolic blood pressure and aortic stiffness. 2) The incident (forward) pressure wave, and not the reflected pressure wave, is associated with greater central pulse pressure.
Source: Journal of Applied Physiology
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: American Heart Association, University of Iowa, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers, G1368206780, G1567652797, University of Iowa Clinical and Translational Science Program (KL2), Blockade of calcium channels and beta adrenergic receptors for physiologic abnormalities in heart failure with preserved ejection fraction (BLOCK HFpEF), VASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BP, Efficacy of Fenofibrate for COVID-19: A phase II randomized controlled trial, Targeting Inflammation to Treat Cardiovascular Aging in Humans, Sympathetic Regulation of Large Artery Stiffness in Humans with Age-Related Isolated Systolic Hypertension, Mechanisms of Early and Late Postpartum Hypertension in Human Preeclampsia, Anxiety-mediated impairments in large elastic artery function and the autonomic nervous system, Iowa Training Program in Kidney and Hypertension Research, Inorganic Nitrate, Large Artery Stiffness and Cerebral Blood Flow in Aged Humans, Understanding Racial Differences in Vascular Function and Ventricular-Vascular Coupling in Heart Failure with Preserved Ejection Fraction, Individual Differences in Obstructive Sleep Apnea, Bridging acute and long-term exercise effects on brain function in older adults, Exercise to improve hippocampal connectivity and learning in older adults, The University of Iowa Clinical and Translational Science Award, Cardiovascular Risk after Preeclampsia - The CRISP study, Developing Oral LT3 Therapy for Heart Failure, G9000139622, G9000149602, Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal), Multidrug Metabolic Approach to Improve Exercise and Skeletal Muscle Oxidative Capacity in HFpEF, Targeting Skeletal Muscle Perfusion and Oxidative Capacity in HFpEF, Genetic determinants of thoracic aortic stiffness and remodeling
OpenAlex ID: W4386306131