Work

Editorial: Ocular neurodegenerative diseases: novel mechanisms, diagnosis, and therapeutic strategies

Year: 2023

Type: editorial

Abstract: Dr. Chen Y et al. have reported a noninvasive diagnosis tool to assess blood flow perfusion in a visual pathway for ocular ischemic syndrome (OIS), which is attributable to chronic hypoperfusion caused by marked carotid stenosis. They have detected blood flow perfusion in a visual pathway by 3D pseudocontinuous ASL (3D-pCASL) using 3.0T MRI (magnetic resonance imaging). The results indicate that that there is a lower blood flow perfusion value in the visual pathway in patients with OIS 5 . Dr. Li Z et al have systemically analyzed independent risk factors for progression of different degrees of diabetic retinopathy as well as non-diabetic retinopathy among type 2 diabetic patients. Then they conclude that young age, short axial higher levels of FBG (fasting blood glucose) and urinary albumin creatinine ratio (UACR) were the independent risk factors for the progression of diabetic retinopathy in type 2 diabetes 12 .Dr. Wareham L et al have presented data on collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease. Their data suggest that repair of underlying collagen in conditions that damage the ocular surface could represent a novel therapeutic avenue in treating a broad spectrum of diseases or injury 13 . Dr. Wang X et al have shown a preliminary study that spectral-domain optical coherence tomography (OCT) combined with ERG in the assessment of conbercept for neovascular age-related macular degeneration (nAMD). Their data suggest that 1) conbercept is useful for the short-term treatment of nAMD; 2) it can safely improve the visual acuity of affected eyes; 3) it can restore the structure and function of the retina 14 .occlusion is independent of circulating immune mediators and is involved in retinal oedema.Their results suggest that 1) intraocular inflammation in RVO is driven primarily by local factors but not circulating immune mediators; 2) intraocular inflammation may promote macular oedema through the PI3K-Akt, Ras, MAPK, and Jak/STAT signaling pathways in RVO; and 3) systemic factors, including cytokines and lipid levels may be involved in retinal microvascular remodeling.Dr. Wang Y et al have assessed that precision and reliability of a novel computerized heterophoria test (CHT). Their data suggest that 1) the CHT can be used to demonstrate excellent inter-and intra-examiner repeatability, as well as good correlation with POCT (prism-neutralized objective cover test); 2) the differences between CHT and POCT are within the permissible range of error; and 3) CHT could provide a precise and reliable measurement for clinical applications 15 .Altogether, this collection of articles emphasizes novel diagnostic and therapeutic approaches for a variety of ocular neurodegeneration diseases, which are necessarily further explored.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2023.1274778

Authors: Wenyi Wu, Yuanjun Li, Tu Hu, Wensi Tao, Dan Wen, Hetian Lei