Work

Human retina-in-a-dish: Unlocking the potential to study mechanisms of inherited retinal disease

Year: 2023

Type: article

Abstract: Inherited retinal diseases affect the structure and function of the retina, leading to moderate to severe vision impairment. In addition to being clinically diverse, they are also genetically heterogeneous and can be attributed to more than 280 genes.1 Although the genetics causal to these diseases are largely known, there are limitations in the model systems available to study inherited retinal diseases. Over the past decade, the advancements made in stem cell biology have allowed for somatic cells to be reprogrammed back to a pluripotent state, opening up avenues to develop stem cell lines from patient fibroblasts, peripheral blood mononuclear cells, or other patient samples.

Source: Molecular Therapy — Methods & Clinical Development

DOI: 10.1016/j.omtm.2023.08.019

Authors: Tiffany Yee, Katherine J. Wert

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Retinal Development and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900