Mapping neuronal ensembles and pattern-completion neurons through graphical models
Year: 2023
Type: article
Abstract: Neuronal ensembles are coordinated groups of neurons that serve as functional building blocks of neural circuits. Here, we present PatMap, a computational toolbox for identifying pattern-completion neurons, key trigger cells capable of reactivating entire neuronal ensembles. We describe a protocol for modeling neural circuits as probabilistic graphical models, linking behavior with specific neuronal ensembles, and identifying their pattern-completion neurons. By linking the cellular and circuit level, PatMap provides a springboard for targeted manipulation and control of neural circuits. For complete details on the use and execution of this protocol, please refer to Carrillo-Reid et al. (2021).1
Source: STAR Protocols
Institution: Columbia University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,500
Awards: G1480873338, Role of neuronal ensembles in cortical plasticity during learning and development, G2941508635, Role of neuronal ensembles in visual processing, The Neglected Subiculum: Decoding and Manipulating Memory Retrieval with Multiphoton Holography, NSF-ANR: REBIRTH: Understanding The Self-Assembly Of The Nervous System of Hydra Vulgaris, Effect of GABAergic inhibition of dendritic spines on synaptic pruning in the medial prefrontal cortex during adolescence
OpenAlex ID: W4386398766