Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
Work
Year: 2023
Type: article
Abstract: Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class inhibitor of the Polθ... more
Source: Nucleic Acids Research
Authors Aleem Syed, František Filandr, Jeffrey Patterson-Fortin, Albino Bacolla, Ramya Ravindranathan +10 more
Institutions Dana-Farber Cancer Institute, Harvard University, University of Calgary, The University of Texas MD Anderson Cancer Center, Lawrence Berkeley National Laboratory +2 more
Cites: 88
Cited by: 18
Related to: 10
FWCI: 3.512
Citation percentile (by year/subfield): 100
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Sustainable Development Goal Good health and well-being
Open Access status: gold
APC paid (est): $3,630