Year: 2023
Type: article
Abstract: Gasdermin D (GSDMD) mediates inflammatory responses by inducing pyroptotic cell death. He et al (Cell 2023; S0092-8674(23)00577-9; https://doi.org/10.1016/j.cell.2023.05.027) identified a novel tolerogenic role for alternative processing of GSDMD. More specifically, a novel N-terminal GSDMD fragment accumulated in proximal small intestinal epithelial cells in response to repeated dietary antigen exposure. This GSDMD fragment translocated to the nucleus and induced expression of MHC Class II molecules, leading to the expansion of tolerogenic type 1 regulatory cells.
Authors: Marc E. Rothenberg, Jean Bousquet
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
OpenAlex ID: W4386443361