Work

Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges

Year: 2023

Type: article

Abstract: BackgroundSingle-cell RNA sequencing (scRNA-seq) technology in neurodegenerative diseases have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. Thus, our study aims to investigate current research trends in scRNA-seq in neurodegenerative diseases and predict future research directions.MethodsDocuments were retrieved from the Web of Science (WOS) database. Impacts and cooperation information were quantified and identified using CiteSpace and VOSviewer based on an analysis of annual publications, journals, countries/regions, institutions, authors and keywords.ResultsThe number of publications on scRNA-seq in neurodegenerative diseases has increased rapidly from 2009 to 2022, and this trend will continue for the following years. Most publications about scRNA-seq in neurodegenerative diseases were from the United States, followed by China. Meanwhile, the University of California System and Harvard University were the most active. Colonna Marco possessed the most cocitations. Most papers on scRNA-seq in neurodegenerative diseases were published in Frontiers In Immunology, while Nature was the top cocited journal. Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS) are frequently studied. microglia, astrocyte, oligodendrocyte and neurons are among the cell types of most concern. At present, the focus of study gradually shifts from disease study to therapeutic research. It is recommended to pay attention to the latest hot spots, such as growth factor, extracellular vesicle and gene regulator networkConclusionscRNA-seq research on neurodegenerative diseases will continue to be a research hotspot. Investigating the roles of different types of nerve cells involved in neurodegenerative diseases will be conducive to developing effective strategies to treat neurodegenerative diseases. Therefore, we analyzed the trends and characteristics of scRNA-seq in neurodegenerative diseases to offer valuable future directions.

Source: iScience

DOI: 10.1016/j.isci.2023.107833