Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model
Year: 2023
Type: article
Abstract: Oxidative/inflammatory stresses due to cardiopulmonary bypass (CPB) cause prolonged microglia activation and cortical dysmaturation, thereby contributing to neurodevelopmental impairments in children with congenital heart disease (CHD). This study found that delivery of mesenchymal stromal cells (MSCs) via CPB minimizes microglial activation and neuronal apoptosis, with subsequent improvement of cortical dysmaturation and behavioral alteration after neonatal cardiac surgery. Furthermore, transcriptomic analyses suggest that exosome-derived miRNAs may be the key drivers of suppressed apoptosis and STAT3-mediated microglial activation. Our findings demonstrate that MSC treatment during cardiac surgery has significant translational potential for improving cortical dysmaturation and neurological impairment in children with CHD.
Authors: Kamil Sarkislali, Kei Kobayashi, Nemanja Sarić, Takuya Maeda, Soichiro Henmi, Fahad A. Somaa, Ankush Bansal, Shao Ching Tu, Camille Leonetti, Chao-Hsiung Hsu, Jingang Li, Pranav Vyas, Yuka Imamura Kawasawa, Tsang-Wei Tu, Paul C. Wang, Patrick J. Hanley, Kazue Hashimoto-Torii, Joseph A. Frank, Richard A. Jonas, Nobuyuki Ishibashi
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,530
Funders: U.S. Department of Defense, National Institutes of Health, Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and Health Disparities
Awards: The developmental origins and fate of neurons in the gyrencephalic neocortex, White Matter Protection in the Fetus with Congenital Heart Disease, Clinical and Translational Science Institute at Childrens National-Mentored Career Development Core, Mesenchymal stem cell for brain protection in the immature brain, Molecular Regulation of Ureagenesis, Clinical and Translational Science Institute at Childrens National, Howard University Research Center for Minority Health and Health Disparities, Cell Therapy for Neuroprotection in Congenital Heart Disease
OpenAlex ID: W4386470683