Work

Age-Related Changes in Neural Noise in a Decision-Making Task

Year: 2023

Type: conference-paper

Abstract: Classical theories suggest that age-related cognitive decline may be caused by increased neural noise.To explicitly test this hypothesis in behaving animals, we quantified single-neuron noise (using Fano Factors) in the cortex, hippocampus, and thalamus of young and old mice.Preliminary results suggest that thalamic neurons show higher trial-to-trial variability in old animals.This work will help us to understand alterations of neural function that may contribute to age-related cognitive decline.

Source: Conference on Cognitive Computational Neuroscience (CCN)

DOI: 10.32470/ccn.2023.1238-0

Authors: Fenying Zang, Anup Khanal, Anne K Churchland, Anne E Urai

Institutions: Leiden University, University of California, Los Angeles, International Brain Laboratory

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: Wellcome Trust, National Institutes of Health, Biotechnology and Biological Sciences Research Council

Awards: International Brain Laboratory, G9000185377