Year: 2023
Type: article
Abstract: Graphene-based nanomaterials (GBNMs), specifically graphene oxide (GO) and reduced graphene oxide (rGO), have shown great potential in cancer therapy owing to their physicochemical properties. As GO and rGO strongly absorb light in the near-infrared (NIR) region, they are useful in photothermal therapy (PTT) for cancer treatment. However, despite the structural similarities of GO and rGO, they exhibit different influences on anticancer treatment due to their different photothermal capacities. In this review, various characterization techniques used to compare the structural features of GO and rGO are first outlined. Then, a comprehensive summary and discussion of the applicability of GBNMs in the context of PTT for diverse cancer types are presented. This discussion includes the integration of PTT with secondary therapeutic strategies, with a particular focus on the photothermal capacity achieved through near-infrared irradiation parameters and the modifications implemented. Furthermore, a dedicated section is devoted to studies on hybrid magnetic-GBNMs. Finally, the challenges and prospects associated with the utilization of GBNM in PTT, with a primary emphasis on the potential for clinical translation, are addressed.
Source: Pharmaceutics
Author: Daniela F. Báez
Institution: University of Talca
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,892
Awards: G1735435095, G4195095261, MICROMOTORS PHOTOTHERMAL AND GUIDED CARRIER AGENTS FOR A POTENTIAL TREATMENT OF GASTRIC CANCER. AN IN-VITRO APPROACH, OGA-LAC DESARROLLO DE UN MICROBIODISPOSITIVO PARA FRENAR CAPACIDADES TUMORALES EN CANCER DE MAMA, G551219040, CENTRO DE ESTUDIOS AVANZADOS DE ENFERMEDADES CRONICAS (ACCDIS), G99091514
OpenAlex ID: W4386476080