Positron Emission Tomography and Magnetic Resonance Imaging in Experimental Human Malaria to Identify Organ-Specific Changes in Morphology and Glucose Metabolism: A Prospective Cohort Study
Year: 2023
Type: book-chapter
Study design: Observational Study
Abstract: The tissue distribution of P. falciparum on autopsy has been well described. In a seminal publication by Marchiafava and Bignami, the greatest concentration of schizonts was found in the brain, followed by the lungs, spleen, bone marrow, liver, and intestines. Magnetic resonance imaging and functional imaging using nuclear medicine such as positron emission tomography may be useful noninvasive methods to study deep tissue processes and organ-specific tropism, particularly in early and non-severe infection. Changes in splenic imaging metrics may be associated with either increased parasite or host activity, or a combination of both. To date, the ability to localize the pathology of malaria in life has been limited, and direct evaluation of sequestration and organ-specific parasite tropism has relied upon animal models and postmortem studies.
Institutions: The University of Queensland, QIMR Berghofer Medical Research Institute, Commonwealth Scientific and Industrial Research Organisation, Mahidol Oxford Tropical Medicine Research Unit, Royal Brisbane and Women's Hospital, Royal Centre for Defence Medicine, Charles Darwin University, Menzies School of Health Research
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Awards: Translational Studies in Malaria, Pathophysiology and treatment of malaria in our region, G3616581437, Tropical diseases: Translating discoveries into better health, Targeting microvascular dysfunction in severe malaria, Tropical Disease - immunity, pathogenesis and vaccine development: global translation, G8365496273
OpenAlex ID: W4386476270