Figure 3 from Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model
Year: 2023
Type: other
Abstract: HDACis upregulate SSTR2 surface expression in three NET cell lines. A and B, SSTR2 surface expression in BON-1 cells was determined by flow cytometry analysis. Cells treated with both VPA at 4 mmol/L (P = 0.0103) and CI-994 at 2.5 μmol/L (P = 0.0416) and 10 μmol/L (P = 0.0205) for 72 hours showed a significant increase in SSTR2 expression. C, QGP-1 cells treated with VPA at 4 mmol/L for 72 hours (P = 0.0366) had a significant increase in SSTR2 expression. D, Cells treated with CI-994 had no significant increase in SSTR2 expression. E, QGP-1 cells treated with CI-994 at 2.5 μmol/L (P = 0.0159) and 5 μmol/L (P = 0.0174) for 5 days showed a significant increase in SSTR2 expression. F, GOT-1 cells treated with CI-994 at 5 μmol/L (P = 0.0051) and 10 μmol/L (P < 0.0001) for 72 hours had a significant increase in SSTR2 expression. Data are expressed as mean ± SEM, (n = 3). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4386485051