Work

Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells

Year: 2023

Type: article

Abstract: Hematopoietic stem cells (HSCs) residing in adult mouse bone marrow (BM) are highly heterogenous, 1 ranging from HSCs executing their full multilineage potential to those with platelet (P)-biased/restricted output. 2 , 3 , 4 These distinct lineage-biased propensities are sustained upon secondary transplantation, and thus largely intrinsic. 1 While adult HSCs derive from definitive fetal HSCs, 5 it is unclear to what degree the lineage biases/restrictions observed in adult BM HSCs, or any other distinct lineage biases/restrictions, have been established before birth.

Source: Cell Research

DOI: 10.1038/s41422-023-00866-4

Authors: Karin Belander Strålin, Joana Carrelha, Axel Winroth, Christoph Ziegenhain, Michael Hagemann-Jensen, Laura M. Kettyle, Amy Hillen, Kari Högstrand, Ellen Markljung, Francesca Grasso, Masafumi Seki, Stefania Mazzi, Yiran Meng, Bishan Wu, Edwin Chari, Madeleine Lehander, Rickard Sandberg, Petter S. Woll, Sten Eirik W. Jacobsen

Institutions: Karolinska University Hospital, Karolinska Institutet, University of Oxford, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,329

Funders: University of Oxford, Karolinska Institutet, Knut och Alice Wallenbergs Stiftelse, Vetenskapsrådet, Medical Research Council

Awards: G6006164261, G6271912076, G6412636814, G7905981415, G8026153621, Unraveling the role of alternative mRNA splicing in the regulation of normal hematopoiesis, G8987631506

OpenAlex ID: W4386492284

FWCI: 1.032

Cites: 16

Cited by: 5

Related to: 10