Year: 2023
Type: review
Abstract: Dopamine is synthesized in the nervous system where it acts as a neurotransmitter. Dopamine is also synthesized in a number of peripheral organs as well as in several types of cells and has organ-specific functions and, as demonstrated more recently, is involved in the regulation of the immune response and inflammatory reaction. In particular, the renal dopaminergic system is very important in the regulation of sodium transport and blood pressure and is particularly sensitive to stimuli that cause oxidative stress and inflammation. This review is focused on how dopamine is synthesized in organs and tissues and the mechanisms by which dopamine and its receptors exert their effects on the inflammatory response.
Institution: George Washington University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,780
Awards: G1403022750, Molecular Mechanisms in Salt Sensitivity of Blood Pressure, Renal dopamine-1 receptor defect in hypertension, G5448949476, Oxidative Stress In The Kidney In Hypertension, Renal Dopamine Receptor and Regulation, GRK4 & Development of Salt Sensitivity, D2 receptor variation and renal dysfunction
OpenAlex ID: W4386525458