Work

Supplementary Figure S3 from A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

Year: 2023

Type: supplementary-materials

Abstract: Supplemental figure S3 data panels and legend accompanying main body figure 4. Supplementary figure S3 demonstrates that ORIC-101 does not inhibit the proliferation of GR independent and GR- NSCLC models. ORIC-101 treatment leads to GR nuclear translocation, binding to FOXA1-GR target genes, and induction of apoptosis. Finally, ORIC-101 is efficacious at doses tolerable to mice and leads to inhibition of FOXA1-GR targets in vivo.

DOI: 10.1158/2767-9764.24101042.v1

Authors: M. Dorso, Payal T. Patel, Aleksandr Pankov, Jacob A. Boyer, Rajesh K. Soni, Isabella S. Del Priore, Omar Hayatt, Amanda Kulick, Connor J. Hagen, Elisa de Stanchina, Melissa R. Junttila, Anneleen Daemen, Lori S. Friedman, Ronald C. Hendrickson, Sarat Chandarlapaty

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4386526138

Cites:

Cited by:

Related to: 10