Work

Molecular and structural insights into the 5‐HT 2C receptor as a therapeutic target for substance use disorders

Year: 2023

Type: article

Abstract: Substance use disorder (SUD) is a chronic condition, with maintained abuse of a substance leading to physiological and psychological alterations and often changes in cognitive and social behaviours. Current therapies include psychotherapy coupled with medication; however, high relapse rates reveal the shortcomings of these therapies. The signalling, expression profile, and neurological function of the serotonin 2C receptor (5‐HT 2C receptor) make it a candidate of interest for the treatment of SUD. Recently, psychedelics, which broadly act at 5‐HT 2 receptors, have indicated potential for the treatment of SUD, implicating the 5‐HT 2C receptor. The modern psychedelic movement has rekindled interest in the 5‐HT 2C receptor, resulting in many new studies, especially structural analyses. This review explores the structural, molecular and cellular mechanisms governing 5‐HT 2C receptor function in the context of SUD. This provides the basis of the preclinical and clinical evidence for their role in SUD and highlights the potential for future exploration.

Source: British Journal of Pharmacology

DOI: 10.1111/bph.16233

Authors: Maleesha Ubhayarathna, Christopher J. Langmead, Natalie A. Diepenhorst, Gregory D. Stewart

Institution: Monash University

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,330