Work

Small extracellular vesicles as potential theranostic tools in central nervous system disorders

Year: 2023

Type: review

Abstract: Small extracellular vesicles(sEVs), a subset of extracellular vesicles with a bilateral membrane structure, contain biological cargoes, such as lipids, nucleic acids, and proteins. sEVs are crucial mediators of intercellular communications in the physiological and pathological processes of the central nervous system. Because of the special structure and complex pathogenesis of the brain, central nervous system disorders are characterized by high mortality and morbidity. Increasing evidence has focused on the potential of sEVs in clinical application for central nervous system disorders. sEVs are emerging as a promising diagnostic and therapeutic tool with high sensitivity, low immunogenicity, superior safety profile, and high transfer efficiency. This review highlighted the development of sEVs in central nervous system disorder clinical application. We also outlined the role of sEVs in central nervous system disorders and discussed the limitations of sEVs in clinical translation.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2023.115407

Authors: Mengtian Guo, Lu Wang, Zhenyu Yin, Fanglian Chen, Ping Lei

Institutions: Capital Medical University, Beijing Chao-Yang Hospital, Capital Medical University, Tianjin Medical University General Hospital, Tianjin Medical University

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,050