Work

Mesoporous Organosilica Nanoparticles with Internal Metal‐Chelating Groups: Transition Metal Uptake and Gd 3+ Relaxivity

Year: 2023

Type: article

Abstract: We prepared novel mesoporous organosilica nanoparticles with internal metal‐chelating diethylenetriametetraacetic acid groups (DTTA‐MSNPs) by co‐condensation and decorated them with fluorescent moieties. We studied the binding of transition metal ions such as copper(II), cobalt (II) and gadolinium (III) by DTTA‐MSNPs, and found high uptake of these metals. In particular, DTTA‐MSNPs uptake ~1.1×10 5 Gd 3+ per particle and possess a high r 1 relaxivity of 15.27 mM −1 s −1 . Thus, DTTA‐MSNPs may find applications in metal sequestration and in MR imaging and neutron capture therapy.

Source: ChemistrySelect

DOI: 10.1002/slct.202301454

Authors: Nathan I. Walton, Pratap C. Naha, David P. Cormode, Ilya Zharov

Institutions: University of Utah, University of Pennsylvania

Language: English

Topic: Mesoporous Materials and Catalysis

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Energy, Office of Science, Basic Energy Sciences