Work

Development of a computational-experimental framework for enhanced mechanical characterization and cross-species comparison of the articular cartilage superficial zone

Year: 2023

Type: article

Abstract: To provide a better understanding of the contribution of specific constituents (i.e. proteoglycan, collagen, fluid) to the mechanical behavior of the superficial zone of articular cartilage, a complex biological tissue with several time-dependent properties, a finite element model was developed. Optimization was then used to fit the model to microindentation experiments. We used this model to compare superficial zone material properties of mature human vs. immature bovine articular cartilage. Non-linearity and stiffness of the fiber-reinforced component of the model differed between human and bovine tissue. This may be due to the more complex collagen architecture in mature tissue and is of interest to investigate in future work.

Source: Computer Methods in Biomechanics & Biomedical Engineering

DOI: 10.1080/10255842.2023.2255712

Authors: Steven P. Mell, Catherine Yuh, Thomas Nagel, Susan Chubinskaya, Hannah J. Lundberg, Markus A. Wimmer

Institutions: Rush University Medical Center, TU Bergakademie Freiberg

Language: English

Topic: Elasticity and Material Modeling

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Award: Mechanobiological Risk Factors for Initiation of Post Traumatic Osteoarthritis