Work

Role of LRRN4 in promoting malignant behavior in a p53- and Rb-defective human fallopian tube epithelial cell line.

Year: 2023

Type: article

Abstract: expression compared to their levels in cells. Overall, this study suggests that LRRN4 may play a role in ovarian carcinogenesis by promoting aggressive malignant behavior in FE25 cells through the activation of the Akt pathway. These findings provide insights into the potential molecular mechanisms underlying ovarian cancer and may have implications for the development of new therapeutic targets for this disease.

Source: PubMed Central

Authors: Yu-Hsun Chang, Kun-Chi Wu, Kai-Hung Wang, Dah-Ching Ding

Institutions: Tzu Chi University, Tzu Chi Foundation, Hualien Tzu Chi Medical Center

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministry of Science and Technology, Taiwan, Buddhist Tzu Chi Medical Foundation

Awards: G1047536327, G264484183, G756314300, G8446891586