Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting.
Year: 2023
Type: article
Abstract: Drug repurposing, also known as drug repositioning, entails the application of pre-approved or formerly assessed drugs having potentially functional therapeutic amalgams for curing various disorders or disease conditions distinctive from their original remedial indication. It has surfaced as a substitute for the development of drugs for treating cancer, cardiovascular diseases, neurodegenerative disorders, and various infectious diseases like Covid-19. Although the earlier lines of findings in this area were serendipitous, recent advancements are based on patient centered approaches following systematic, translational, drug targeting practices that explore pathophysiological ailment mechanisms. The presence of definite information and numerous records with respect to beneficial properties, harmfulness, and pharmacologic characteristics of repurposed drugs increase the chances of approval in the clinical trial stages. The last few years have showcased the successful emergence of repurposed drug immunotherapy in treating various diseases. In this light, the present review emphasises on incorporation of drug repositioning with Immunotherapy targeted for several disorders.
Source: PubMed Central
Authors: Vishakha Anand Pawar, Anuradha Tyagi, Chaitenya Verma, Kanti Prakash Sharma, Sekhu Ansari, Indra Mani, Shailesh Kumar Srivastva, Pradeep Kumar Shukla, Antresh Kumar, Vinay Kumar
Institutions: The University of Texas MD Anderson Cancer Center, Institute of Nuclear Medicine & Allied Sciences, The Ohio State University Wexner Medical Center, The Ohio State University, Central University of Haryana, Cincinnati Children's Hospital Medical Center, University of Delhi, Sam Higginbottom Institute of Agriculture
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4386592935