Anti-Diarrhoeal Activity of the Aqueous Extract of the Bark of Cinnamomum Zeylanicum Linn in Mice
Year: 2012
Type: article
Abstract: Purpose: The plant, Cinnamomum zeylanicum (Laureceae), is a small, ever green plant which is native to southern India and it has been reported to possess a number of medicinal properties. The purpose of the present study was to evaluate the anti-diarrhoeal activity of the aqueous extract of the bark of Cinnamomum zeylanicum which is used traditionally as folk medicine, by using a castor oil and MgSO4 (Magnesium Sulphate) induced diarrhoea model. Methods: The aqueous extract of the bark of this plant at graded doses (100mg/kg, 200mg/kg body weight) was investigated for its anti-diarrhoeal activity in terms of the reduction in the rate of defaecation and the consistency of faeces in castor oil, Mgso4 induced diarrhoea. To understand the mechanism of its antidiarrhoeal activity, its effect was further evaluated on the gastrointestinal transit time with charcoal meal. Results: The bark extract showed significant (p<0.05) inhibitory activity against castor oil and Mgso4 induced diarrhoea. There was a significant reduction in the gastro-intestinal motility which was observed by using the charcoal meal test in mice. Conclusion: The results which were obtained in this study substantiated the anti-diarrhoeal effects of the aqueous extract of Cinnamomum zeylanicum Linn and its use by the traditional practitioners in the treatment of diarrhoea.
Authors: HARI JAGANNADHA RAO, LAKSHMI
Institution: NRI Medical College
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4386593801