Year: 2023
Type: article
Abstract: Alzheimer's disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.
Source: Biosensors
DOI: 10.3390/bios13090880
Authors: Feng Gao, Fang Li, Jianhao Wang, Hang Yu, Xiang Li, Hongyu Chen, Jiabei Wang, Dongdong Qin, Yiyi Li, Songyan Liu, Xi Zhang, Zhi-Hao Wang
Institution: Renmin Hospital of Wuhan University
Language: English
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,447
Awards: G2860148509, G8231351099
OpenAlex ID: W4386601211