Influence of treatment intensity and medical comorbidities in older adults with peripheral T cell lymphoma
Year: 2023
Type: article
Study design: Observational Study
Abstract: We conducted a population-based study of patients >65 years, diagnosed 2008-2017, with peripheral T-cell lymphoma (PTCL) using SEER-Medicare. Associations between PTCL subtype, treatment regimen, comorbidity, and mortality were assessed using the Kaplan-Meier method and multivariable Cox regression. Amongst the 2,546 patients, the median age was 77 years (interquartile range, 71–83). 5-year overall survival (OS) ranged from 22.2% to 37.3% depending on PTCL subtype. The most common frontline regimen was cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). 5-year OS rate was 47.0% for patients treated with etoposide + CHOP (N = 67; CHOEP), 33.7% for those treated with CHOP (N = 732), and 23.8% for patients treated with non-anthracycline-containing regimens (N = 105; p < 0.001). In patients without comorbidities, CHOEP remained independently associated with improved OS (HR 0.52, 95% CI,0.30-0.91). Median OS was 1.2 years from initiation of second-line therapy (N = 228) independent of treatment regimen. Frontline but not second-line treatment regimen is associated with OS in older patients with PTCL.
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Susan G. Komen for the Cure, Cancer Prevention and Research Institute of Texas, California Department of Public Health, Leukemia and Lymphoma Society, University of Southern California, Centers for Disease Control and Prevention, University of Texas MD Anderson Cancer Center, University of California, San Francisco, National Cancer Institute, Cairo University, National Cancer Institute
Awards: G111615301, G1352184354, G1358719649, G1395202410, G1666956106, G2187125108, G2337224928, G2612351997, G293715275, G3448447748, G3509688676, G3901845577, G3987779641, G4332884407, G4822910251, G4854421162, G4878091559, G504639888, G5631299761, G6951404960, G7290139498, G8083727551, G840739938, G8509442309, G9000055636, G946791773
OpenAlex ID: W4386726224