Year: 2023
Type: article
Abstract: Perioperative Neurocognitive Disorders (PND) are increasingly recognized as an area of concern in our aging surgical population 1,2 .For decades, postoperative disturbances in cognition and behavior were studied in the context of postoperative delirium (POD) or postoperative cognitive dysfunction (POCD).More recently, PND has emerged as a more inclusive overarching term, based on Diagnostic and Statistical Manual 5th edition (DSM-V) terminology for neurocognitive disorder, which includes preexisting cognitive disorders, POD, and POCD 1 .Over the past three decades significant progress has been made to improve the quality of PND studies by standardizing nomenclature and how PND are defined, measured, and assessed to better compare results across studies 1,2 .However major gaps still exist in patient cohort selection, which often focuses on convenience samples that in turn contribute to poor external validity and generalizability of results to a more diverse population 1,3 .Ethnoracial factors and social determinants of health, encompassing race, ethnicity, primary language, socioeconomic status, education and other social and racial factors, are known to play a role in neurocognitive disorders such as Alzheimer's Disease and Related Dementias (ADRD) and PND 4 .Populations underrepresented in PND research tend to be from developing countries as well as marginalized groups in high-income countries 5 .Ethnoracial factors and social determinants of health have been shown to impact disease progression, phenotype expression, and treatment response, which inform risk stratification and management strategies 4 .The reasons for this are likely multifactorial and vary from biomarker expression and genetic predisposition to environmental exposures 4 .Another reason may be a lack of preventative care or adequate education on early signs or symptoms
Source: Anesthesia & Analgesia
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Bristol-Myers Squibb, University of Pittsburgh, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities, Clinical and Translational Science Institute, University of California, Los Angeles
Awards: G2050812788, G343705321, G355665738, G562934659, G67549176, G6805630359, G7201947750, Biomedical Informatics Tools for Applied Perioperative Physiology, G837983217, G9000031392, Center for Health Innovation and Maximizing Elder Care, Multidisciplinary Anesthesiology and Perioperative Medicine Research Training Program
OpenAlex ID: W4386758012