MjCyc: Rediscovering the pathway-genome landscape of the first sequenced archaeon, Methanocaldococcus (Methanococcus) jannaschii
Year: 2024
Type: article
Abstract: The genome of Methanocaldococcus (Methanococcus) jannaschii was the first Archaeal genome to be sequenced, back in 1996. Subsequent cycles of sequence-based annotation led to its first metabolic reconstruction in 2005. Now, with an influx of experimental results and function assignments, we have re- annotated M. jannaschii creating a new resource with novel information and testable predictions in a pathway-genome database at BioCyc.org. Our reannotation has resulted in 652 function assignments with enzyme roles, accounting for a third of the total number of protein-coding entries for this genome. This effort unveiled 883 reactions, 540 enzymes and 142 individual pathways. However, despite notable progress in computational genomics, a third of the genome remains functionally uncharacterized. The publicly available MjCyc pathway-genome database holds great potential for the wider community to conduct research on the biology of methanogenic Archaea.
Source: iScience
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,150
Funders: U.S. Department of Energy, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Innovative Research Group Project of the National Natural Science Foundation of China, Joint Genome Institute, European Commission, National Institutes of Health, Office of Science, Research Committee, Aristotle University of Thessaloniki, European Regional Development Fund, National Institute of Allergy and Infectious Diseases
OpenAlex ID: W4405040657