Figure 4 from Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Year: 2023
Type: other
Abstract: Association of biomarkers of interest with clinical outcomes by treatment group in chemotherapy-naïve patients. A, Changes in transcriptional DDR features between primary and recurrent disease. P values presented from t tests comparing primary and recurrent scores in paired samples. PT, primary tumor; REC, recurrent tumor. B, Association of biomarkers with objective response in chemotherapy-naïve patients. Odds ratios for each biomarker are presented from univariable logistic regression models. Stars indicate that an odds ratio could not be estimated due to colinearity (i.e., a cutoff could perfectly separate responders from nonresponders). C, Biomarker by response in chemotherapy-naïve, carboplatin-treated patients for biomarkers where a model could not be fitted due to a perfect cutoff between responders and nonresponders. D, Association of biomarkers with PFS in chemotherapy-naïve patients. Model coefficients of each biomarker are presented from linear regression of restricted mean PFS. Ninety-five percent confidence intervals are shown.
Authors: Holly Tovey, Orsolya Sipos, Joel S. Parker, Katherine A. Hoadley, Jelmar Quist, Sarah Kernaghan, Lucy Kilburn, Roberto Salgado, Sherene Loi, Richard D. Kennedy, Ioannis Roxanis, Patrycja Gazinska, Sarah E. Pinder, Judith Bliss, Charles M. Perou, Syed Haider, Anita Grigoriadis, Andrew Tutt, Maggie Chon U. Cheang
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4386777872