High RIPK3 expression is associated with a higher risk of early kidney transplant failure
Year: 2023
Type: article
Study design: Observational Study
Abstract: Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained from renal allografts 10 minutes after onset of reperfusion. RIPK3 was primarily detected in proximal tubular cells and distal tubular cells, both of which are affected by IRI. Time-to-event analysis revealed that high RIPK3 expression is associated with a significantly higher risk of one-year transplant failure and prognostic for one-year (death-censored) transplant failure independent of donor and recipient associated risk factors in multivariable analyses. The RIPK3 score also correlated with deceased donation, cold ischemia time and the extent of tubular injury.
Source: iScience
Authors: Adam Wahida, Christoph Schmaderer, Maike Büttner-Herold, Caterina Branca, Sainitin Donakonda, Flora Haberfellner, Carlos Torrez, Jessica Schmitz, Tobias Schulze, Tobias Seibt, Rupert Öllinger, Thomas Engleitner, Bernhard Haller, Katja Steiger, Roman Günthner, Georg Lorenz, Monica Yabal, Quirin Bachmann, Matthias C. Braunisch, Philipp Moog, Edouard Matevossian, Volker Aßfalg, Stefan Thorban, Lutz Renders, Martin R. Späth, Roman-Ulrich Müller, Dirk L. Stippel, Wilko Weichert, Julia Slotta-Huspenina, Sibylle von Vietinghoff, Ondrej Viklicky, Douglas R. Green, Roland Rad, Kerstin Amann, Andreas Linkermann, Jan Hinrich Bräsen, Uwe Heemann, Stephan Kemmner
Institutions: TUM Klinikum, Technical University of Munich, Friedrich-Alexander-Universität Erlangen-Nürnberg, Medizinische Hochschule Hannover, LMU Klinikum, Ludwig-Maximilians-Universität München, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne, University of Bonn, University Hospital Bonn, Institute of Clinical and Experimental Medicine, St. Jude Children's Research Hospital, Albert Einstein College of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,336
Awards: G1043868716, Posttranslationale kontrolle des entzündlichen Zelltodes durch XIAP, G135111394, G1465392264, G1503510435, G1633875375, G2000294849, G2566998440, G2606557956, G3055204393, G3819083040, G5641494386, G6234385608, Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension
OpenAlex ID: W4386812723