Work

Region-targeted Bilayer Coating Technology for Ingestible Devices and Systems

Year: 2022

Type: conference-paper

Abstract: We present a pH-responsive bilayer packaging strategy to protect capsule components intended for actuation in the small intestine from stomach acid.The bilayer is resistant to stomach acid but is removed in the small intestine (neutral pH).This structure consists of a water-soluble support layer, polyethylene glycol (PEG), and a pH-responsive polymer coating, Eudragit.We also demonstrate a realistic intestinal simulation apparatus to test physical bilayer removal against intestinal tissue with physiologically relevant forces.Using this simulator, bilayer removal was accomplished in approximately 15.6 min.This technology represents a low-complexity, versatile, and reliable approach to protect ingestible capsule components.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2022.72

Authors: Michael A. Straker, Joshua Levy, Justin Stine, Vivian Borbash, Luke Beardslee, Reza Ghodssi

Institution: University of Maryland, College Park

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, Division of Electrical, Communications and Cyber Systems

Awards: Closed-Loop Sensing and Actuation for Gastrointestinal Capsule Systems, G497240539