Work

Biomimetic Anchoring System for Sustained and Localized Gastrointestinal Drug Delivery

Year: 2022

Type: conference-paper

Abstract: We present a novel application of biomimetic spiny microneedles for an anchoring drug deposit (SMAD) enabling longterm localized treatment of lesions within the GI tract.Mechanical characterizations in ex-vivo intestinal tissue demonstrate a 22-fold higher anchoring force than traditional conical molded microneedle (MMN) arrays.Additionally, payload diffusion experiments demonstrate that the SMAD can predictably deliver drugs, locally, to a site of interest with comparable performance to MMNs, indicated by strong logarithmic correlation (R 2 =0.9773) across SMAD and MMN data.We anticipate this work will permit exploration of localized GI tract drug delivery, facilitating targeted treatment to reduce adverse drug side effects.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2022.22

Authors: Joshua A. Levy, Michael Straker, Luke Beardslee, Reza Ghodssi

Institution: University of Maryland, College Park

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, Division of Electrical, Communications and Cyber Systems