Work

Miniaturized Capsule System for Hydrogen Sulfide Detection in the Gastrointestinal Tract

Year: 2022

Type: conference-paper

Abstract: This work presents an ingestible capsule platform for realtime, wireless detection of hydrogen sulfide (H2S) as a biomarker of inflammation in the gastrointestinal (GI) tract.The design integrates an analog front-end (AFE) potentiostat and Bluetooth Low Energy (BLE) microcontroller on a flex-rigid printed circuit board (PCB) with a miniaturized electrochemical H2S sensor to perform amperometric measurements with the desired capsule form factor. Packaged within a 3D-printed shell, the capsule successfully monitors physiological H2S concentrations within a linear range of 3.7-12 ppm with sensitivity of 0.17 μA/ppm, providing a framework for non-invasive, on-site monitoring of gaseous biomarkers in the GI tract.

Source: Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop)

DOI: 10.31438/trf.hh2022.18

Authors: Justin M. Stine, Santiago Botasini, Luke Beardslee, Joshua Levy, Reza Ghodssi

Institution: University of Maryland, College Park

Language: English

Topic: Analytical Chemistry and Sensors

Subfield: Bioengineering

Field: Chemical Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, Division of Electrical, Communications and Cyber Systems