Work

The Psychedelic N , N -Dipropyltryptamine Prevents Seizures in a Mouse Model of Fragile X Syndrome via a Mechanism that Appears Independent of Serotonin and Sigma1 Receptors

Year: 2023

Type: article

Abstract: knockout mice, but neither serotonin nor sigma1 receptor antagonists prevented this action. Thus, DPT might have neurotherapeutic effects independent of its serotonergic psychedelic properties. However, DPT also caused seizures at high doses, showing that DPT has complex dose-dependent in vivo polypharmacology.

Source: ACS Pharmacology & Translational Science

DOI: 10.1021/acsptsci.3c00137

Authors: Richa Tyagi, Tanishka S. Saraf, Clinton E. Canal

Institutions: Mercer University, Mercer University Health Sciences Center

Language: English

Topic: Psychedelics and Drug Studies

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,000