Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

Year: 2023

Type: article

Abstract: There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017-2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non-Panton-Valentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)-SCCmec IV, PVL-producer-(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

Source: American Journal of Tropical Medicine and Hygiene

DOI: 10.4269/ajtmh.23-0054

Institutions: Universidad Peruana Cayetano Heredia, Hospital Nacional Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, National University of Saint Anthony the Abbot in Cuzco, Antenor Orrego Private University, EsSALUD, Universidad Privada de Tacna, Henry Ford Health, Instituut voor Tropische Geneeskunde, KU Leuven

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Fogarty International Center

Award: University of California Launching Future Leaders in Global Health Research Training Program

OpenAlex ID: W4386826829