Work

Expanding our grasp of two-component signaling in Clostridioides difficile

Year: 2023

Type: editorial

Abstract: ABSTRACT The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23 ) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile .

Source: Journal of Bacteriology

DOI: 10.1128/jb.00188-23

Authors: Orlando Berumen Alvarez, Erin B. Purcell

Institution: Old Dominion University

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, National Institute of Allergy and Infectious Diseases