Work

FIGURE 3 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Year: 2023

Type: other

Abstract: NLRP3 inhibition reduces PDAC progression. A, Tumor volume and weight in WT and Nlrp3−/− mice (n = 8/group). B, Tumor volume and weight in mice fed standard (STD) or OL1177 (OLT) diet (n = 16/group). C, Survival curve in mice fed standard or OLT1177 diet (n = 20/group). D, Flow cytometry analysis of CD8, CD8/PD1, CD8/CD44/PD-1 cells in primary tumors of mice in B (n = 5/group). E, Flow cytometry analysis of memory (CD62L+/CD44+), naïve (CD62L+/CD44−), and effector (CD62L−/CD44+) CD8 cells in primary tumors of mice in D–F (n = 5/group). F, Gene expression of Ifng, Prf1, and Gzmb in primary tumors of mice in B (n = 5/group). Data expressed as mean ± SEM; ****, P < 0.0001; **, P < 0.01; *, P < 0.05.

DOI: 10.1158/2767-9764.24168343.v1

Authors: Jesus Amo-Aparicio, Adrian Dominguez, Shaikh M. Atif, Alberto Dinarello, Tania Azam, Kibrom M. Alula, Miles Piper, Christopher H. Lieu, Robert W. Lentz, Alexis D. Leal, Stacey M. Bagby, Wells A. Messersmith, Sana D. Karam, Charles A. Dinarello, Todd M. Pitts, Carlo Marchetti

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4386888038

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