Work

FIGURE 8 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Year: 2023

Type: other

Abstract: NLRP3 inhibition increases gemcitabine efficacy. A, Tumor volume and weight in mice treated with vehicle (PBS), gemcitabine (GEM), OLT1177 (OLT), and GEM+OLT (n = 8/group). B, Flow cytometry analysis of Ki67 expression in CD45− cells from the primary tumors obtained in A (n = 8/group). C, Viability of human PDAC organoids after 72 hours of culture in presence of gemcitabine (GEM) or OLT1177 (OLT; n = 3). D, Representative images of organoids from C. E, NLRP3 expression in primary tumors obtained in A (n = 3/group). Data expressed as mean ± SEM; ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05.

DOI: 10.1158/2767-9764.24168328

Authors: Jesus Amo-Aparicio, Adrian Dominguez, Shaikh M. Atif, Alberto Dinarello, Tania Azam, Kibrom M. Alula, Miles Piper, Christopher H. Lieu, Robert W. Lentz, Alexis D. Leal, Stacey M. Bagby, Wells A. Messersmith, Sana D. Karam, Charles A. Dinarello, Todd M. Pitts, Carlo Marchetti

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4386888064

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