Work

FIGURE 1 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Year: 2023

Type: other

Abstract: NLRP3 expression and activation are increased in PDAC biopsy. A, NLRP3, ASC, IL1β, and IL18 median expression levels in human PDAC biopsy and normal pancreas samples (TCGA dataset). B, Immunofluorescence staining from NLRP3 (red) and ASC (green) in biopsy of normal pancreas (n = 2) and patients with PDAC (n = 4). Each row represents a single patient. C, Quantification of ASC specks–like structure samples in B. *, P < 0.05.

DOI: 10.1158/2767-9764.24168349

Authors: Jesus Amo-Aparicio, Adrian Dominguez, Shaikh M. Atif, Alberto Dinarello, Tania Azam, Kibrom M. Alula, Miles Piper, Christopher H. Lieu, Robert W. Lentz, Alexis D. Leal, Stacey M. Bagby, Wells A. Messersmith, Sana D. Karam, Charles A. Dinarello, Todd M. Pitts, Carlo Marchetti

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4386897035

Cites:

Cited by:

Related to: 10