FIGURE 4 from Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment
Year: 2023
Type: other
Abstract: NLRP3 activation mediates a Th2-like inflammatory response. A, Flow cytometry analysis of CD4, CD4/PD1, CD4/CD44/PD-1 cells in primary tumors of mice fed standard (STD) and OLT1177 (OLT)-enriched diets (n = 5/group). B, Flow cytometry analysis of memory (CD62L+/CD44+), naïve (CD62L+/CD44−), and effector (CD62L−/CD44+) CD4 cells in primary tumors of mice fed STD and OLT-enriched diets (n = 5/group). C, Gene expression of Il2, Il4, and Il10 in primary tumors of mice of mice fed STD and OLT-enriched diets (n = 5/group). D, COX-2 and PGE2 levels measured by ELISA in primary tumors of mice of mice fed STD and OLT-enriched diets (n = 5/group). E, PGE2 levels measured by ELISA in primary tumors of mice of mice fed STD and OLT-enriched diets (n = 5/group). Data expressed as mean ± SEM; ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4386897114