Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck
Year: 2023
Type: article
Abstract: Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.
Source: Cancers
Institutions: Emory University, Winship Cancer Institute, SIU Medicine, Bar-Ilan University, Universidad de Oviedo, Hospital Universitario Central de Asturias, Centro de Investigación Biomédica en Red de Cáncer, Instituto de Investigación Sanitaria del Principado de Asturias, Institute of Oncology Ljubljana, University of Helsinki, Helsinki University Hospital, Universidade de São Paulo, AC Camargo Hospital, Memorial Sloan Kettering Cancer Center
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,892
Funder: National Cancer Institute
Award: Cancer Center Support Grant
OpenAlex ID: W4386996039