Work

Structural basis of dsRNA recognition by the J2 monoclonal antibody

Year: 2023

Type: article

Abstract: dsRNA is often sensed as a hallmark of viral infection to trigger an innate immune response.In the constant arms race between viruses and the host, some host protein factors are activated upon the recognition of non-self dsRNA to curb the infection 1 (e.g.RIG-I/MDA5, PKR, RNase L, TLRs).Given the importance of dsRNA to trigger an immune response and its prevalence in RNA structures, several methods to detect or to isolate dsRNA have been developed.For instance, the J2 monoclonal antibody is widely

Source: Acta Crystallographica Section A Foundations and Advances

DOI: 10.1107/s2053273323098522

Authors: Charles Bou-Nader, Ankur Bothra, Iilias Skeparnias, David N. Garboczi, Stephen H. Leppla, Jinwei Zhang

Institutions: National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4387046014

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