Work

Visualization of the human manganese superoxide dismutase product inhibition mechanism and protonation states

Year: 2023

Type: article

Abstract: About 25% of known enzymes are oxidoreductases that catalyze the electron transfers that life depends on.To chemically accelerate redox reactions to the rates needed for life, oxidoreductases couple the transfer of electrons to the transfer of protons in a process called proton-coupled electron transfer (PCET).The biochemistry behind enzymes utilizing PCETs is not well understood as it requires precise definition of the proton donors/acceptors in tandem with electron transfer steps.Of particular note are oxidoreductases that regulate the concentration of reactive oxygen species (ROS) in cells through PCET-mediated redox reactions.ROS levels mediate mitophagy and programmed cell death and dysfunction of oxidoreductases responsible for limiting ROS concentrations contribute to cardiovascular disease, neurological disease, and cancer progression.

Source: Acta Crystallographica Section A Foundations and Advances

DOI: 10.1107/s2053273323099436