Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics
Year: 2023
Type: article
Abstract: This study successfully established a translationally relevant, murine neonatal parenteral nutrition (PN) model. Short-term PN is sufficient to induce hepatitis-associated cholestasis in a neonatal murine model that can be used to understand disease in early life. The administration of antibiotics during PN protects animals from bacterial translocation and proinflammatory responses but induces unique metabolic shifts that may predispose the liver toward early steatosis.
Authors: Tahliyah S. Mims, Roshan Kumari, Cameron Leathem, Karen Antunes, Sydney Joseph, Mei-I Yen, Danielle Ferstl, Sophia M. Jamieson, Austin Sabbar, Claudia Biebel, Nikolai Lazarevic, Nathaniel B. Willis, Lydia Henry, Chi-Liang E. Yen, Joseph P. Smith, Ankush Gosain, Marlies Meisel, Kent A. Willis, Ajay J. Talati, Mohammad. T. Elabiad, Brianne Hibl, Joseph F. Pierre
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Basic Research Laboratory, Division of Diabetes, Endocrinology, and Metabolic Diseases
Awards: Role of probiotic Lactobacillus reuteri in orchestrating systemic anti-tumor immunity, G4356643608, The gut-lung axis influences the development of bronchopulmonary dysplasia, G478468884, Modeling Host-Fungal Interactions in Hirschsprung-Associated Enterocolitis, G741512359, G7779876677, Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk., Metabolism and Nutrition Training Program, Systemic immunoregulatory consequences of bacterial translocation during health and disease, Role of microbially-derived metabolites in anti-tumor immunity in breast cancer
OpenAlex ID: W4387078147