Work

Mild dehydration effects on the murine kidney single-nucleus transcriptome and chromatin accessibility

Year: 2023

Type: article

Abstract: The kidney consists of >30 cell types that work collectively to maintain fluid-electrolyte balance. Kidney single-nucleus transcriptomes and chromatin accessibility profiles from male and female control (ad libitum water and food) or mildly dehydrated mice (ad libitum food, water deprivation) were determined. Mild dehydration caused hundreds of cell- and sex-specific transcriptomic changes, even though the kidney function to conserve water was the same.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00161.2023

Authors: Nha Van Huynh, Cassidy Rehage, Kelly A. Hyndman

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Single-cell and spatial transcriptomics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Award: Lysine Acetylation and the Regulation of Vasopressin/Aquaporin System in the Principal Cell