Year: 2023
Type: article
Study design: Observational Study
Abstract: INTRODUCTION Sleep duration has been associated with dementia and stroke. Few studies have evaluated sleep pattern–related outcomes of brain disease in diverse Hispanics/Latinos. METHODS The SOL‐INCA (Study of Latinos‐Investigation of Neurocognitive Aging) magnetic resonance imaging (MRI) study recruited diverse Hispanics/Latinos (35–85 years) who underwent neuroimaging. The main exposure was self‐reported sleep duration. Our main outcomes were total and regional brain volumes. RESULTS The final analytic sample included n = 2334 participants. Increased sleep was associated with smaller brain volume (βtotal_brain = −0.05, p < 0.01) and consistently so in the 50+ subpopulation even after adjusting for mild cognitive impairment status. Sleeping >9 hours was associated with smaller gray (βcombined_gray = −0.17, p < 0.05) and occipital matter volumes (βoccipital_gray = −0.18, p < 0.05). DISCUSSION We found that longer sleep duration was associated with lower total brain and gray matter volume among diverse Hispanics/Latinos across sex and background. These results reinforce the importance of sleep on brain aging in this understudied population. Highlights Longer sleep was linked to smaller total brain and gray matter volumes. Longer sleep duration was linked to larger white matter hyperintensities (WMHs) and smaller hippocampal volume in an obstructive sleep apnea (OSA) risk group. These associations were consistent across sex and Hispanic/Latino heritage groups.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13451
Institutions: University of California San Diego, Wayne State University, San Diego State University, University of Miami, Brigham and Women's Hospital, Harvard University, Albert Einstein College of Medicine, University of North Carolina at Chapel Hill, University of Illinois Chicago, University of California Davis Medical Center, University of California, Davis
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Funders: National Science Foundation, Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1042216835, G1081972346, G1301356587, G1312369436, UC Davis Alzheimer's Disease Core Center, Hispanic Community Health Study, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G1587824183, G1666450717, MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos, G1917633662, G2135211244, G2135293100, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2644289446, G2970637568, G3062787641, G3119025348, Hispanic Community Health Study, G3677686024, G3722034730, G3838006641, G3952816605, Study of Latinos Investigation of Neurocognitive Aging 2, G4121762840, Hispanic Community Health Study, G4421869008, G4552920371, San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program, G4799736536, G4860668542, G4989378220, G528357465, G5365244667, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G5935820280, G5972125204, G6075306088, G6156511736, G6417049743, Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse Latinos, G6585687856, G6744188800, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G7408420985, G7513901258, G7678550560, G8102260223, G820454163, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease, UC Davis Alzheimer's Disease Research Center, Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)
OpenAlex ID: W4387157806