Work

Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension

Year: 2023

Type: article

Abstract: Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500-1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the development of the disease. Here, we report two human induced pluripotent stem cell (iPSC) lines generated from IPAH patients. Both cell lines provide valuable insight into the molecular and cellular mechanisms of IPAH and can be used to further understand the disease.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2023.103218

Authors: Gaoxian Chen, Lorena Orozco, Sophia Parmisano, James W.S. Jahng, Carlos D. Vera, Yan Zhuge, Joseph C. Wu, Detlef Obal

Institutions: Stanford Medicine, Stanford Cardiovascular Institute, Stanford University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,210

Funders: Stanford University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, Stanford Maternal and Child Health Research Institute

Awards: G2168952822, Detection/Dysplastic Epithelium/Gastrointestinal Tract, G5170875372, G5363357612, Genome Editing of Human iPSCs to Study Inherited Hypertrophic Cardiomyopathy, Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology

OpenAlex ID: W4387212336

FWCI: 0.087

Cites: 5

Cited by: 1

Related to: 10