Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA2 variants
Year: 2023
Type: article
Abstract: Germline pathogenic variants in the BRCA2 gene are strongly correlated with an elevated risk of developing breast cancer. Two specific BRCA2 variants, c.8167G>C (p.Asp2723His) and c.1583del (p.Asn528fs), have been identified from individuals with a family history of breast cancer. Here we generated two iPSC lines from breast cancer patients who are heterozygous carriers of these two variants. These iPSCs exhibit pluripotency and demonstrate the capability to differentiate into three germ layers. These iPSC lines represent a valuable resource for personalized pre-clinical research, offering new opportunities to explore the underlying mechanisms of breast cancer and develop targeted therapeutic approaches.
Source: Stem Cell Research
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,210
Awards: G2168952822, G5058312027, G5170875372, G6816056403, Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy, Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell Multiomics, Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs, Elucidating Anthracycline-Induced Cell Type-Specific Cardiovascular Toxicity with CRISPRi/a Screens
OpenAlex ID: W4387246748