Supplementary Figure S17 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
Year: 2023
Type: supplementary-materials
Abstract: Differential methylation of MM relevent genes. Volcano plots of the CpG probes (probes=2498) across chromosome 1 between MM (n=161) and normal PC (n=3), as a result there are 378 probes (genes=360) that are significantly hypomethylated in MM on in comparison to the normal phenotype and 5 probes (genes=7) are significantly hypermethylated. The plot is further annotated to show the probe associated with A. the GEP70 genes located on chromosome 1 (n=20, p-arm=12, q-arm=8), and B. genes that have been previously implicated as driver genes of the gain/1amp(1q) phenotype in MM (n=20, p-arm=7, q-arm=13).
Authors: Eileen M. Boyle, Patrick Blaney, James H. Stoeckle, Yubao Wang, Hussein Ghamlouch, Dylan Gagler, Marc Braunstein, Louis Williams, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, Jason Avigan, Alexander Li, Monica Jinsi, David Kaminetzsky, Arnaldo Arbini, Lydia Montes, Jill Corre, Even H. Rustad, Ola Landgren, Francesco Maura, Brian A. Walker, Michael Bauer, Benedetto Bruno, Aristotelis Tsirigos, Faith E. Davies, Gareth J. Morgan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4387263462
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