Supplementary Figure S18 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
Year: 2023
Type: supplementary-materials
Abstract: Concurrent Hypomethylation and Overexpression Probes. The dot plot (top) displays the distribution of statistically significant CpG probes with difference in group mean methylation beta value, where the greater the value is a proxy for loss of methylation at the CpG probe. The probes are oriented by genomic locus across chromosome 1 with annotations for the midpoint of the recurrent gained regions on the 1q arm. The area graph (bottom) displays the ratio of probes that are significantly differentially methylated in any given 2MB window across chromosome 1. The highlighted region corresponds to the 1q arm.
Authors: Eileen M. Boyle, Patrick Blaney, James H. Stoeckle, Yubao Wang, Hussein Ghamlouch, Dylan Gagler, Marc Braunstein, Louis Williams, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, Jason Avigan, Alexander Li, Monica Jinsi, David Kaminetzsky, Arnaldo Arbini, Lydia Montes, Jill Corre, Even H. Rustad, Ola Landgren, Francesco Maura, Brian A. Walker, Michael Bauer, Benedetto Bruno, Aristotelis Tsirigos, Faith E. Davies, Gareth J. Morgan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4387264253
Cites:
Cited by:
Related to: